Studies on Chemotherapeutics. XXXIV

Clinical studies of induction agents. XXXIV: Further investigations with ethanol.

A re-evaluation of dilute (8 per cent w/v) ethanol as a sole intravenous anaesthetic agent (with various premedicants), in 300 patients undergoing minor gynaecological surgery, is reported. It confirms that adequate doses will rapidly induce sleep. Sedative or analgesic premedication, notably with promethazine, can make ethanol a more effective and acceptable induction agent, with the maximum d...

Studies on the helminth fauna of Alaska. XXXIV. The parasites of wolves, Canis lupus L.

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Developments in Practice XXXIV: Application Portfolio Management

Nanoformulations of Antimicrobial Chemotherapeutics

Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...